What daily iron dose is commonly used to treat pediatric iron deficiency anemia?

• A. 1–2 mg/kg per day
• B. 2–4 mg/kg per day
• C. 5–7 mg/kg per day
• D. 3–6 mg/kg per day, typically divided into 2 doses

Answer: (D)

Oral iron therapy for pediatric iron deficiency anemia uses elemental iron dosed by body weight at about 3–6 mg per kilogram per day, usually split into two doses. Splitting the dose helps with tolerability and absorption because iron absorption can be limited by high daily amounts, and dividing it reduces GI side effects like nausea, constipation, and upset stomach. For best results, take the iron with a source of vitamin C to boost absorption, and try to avoid taking it with calcium-containing foods or antacids around the dosing time, since calcium can hinder iron absorption. This dosing range provides enough iron to replenish stores efficiently while keeping side effects manageable; clinicians tailor within this range based on severity and response, and therapy typically continues for about three months after hemoglobin normalizes to rebuild iron stores, with follow-up labs to confirm improvement.